Be sure to mention the medications listed in the important warning section and any of the following other antibiotics; anticoagulants blood thinners such as warfarin coumadin, jantoven ; certain antidepressants; antipsychotics medications to treat mental illness ; cimetidine tagamet ; cyclosporine gengraf, neoral, sandimmune ; diuretics water pills ; insulin and oral medications for diabetes such as glyburide diabeta, glynase, in glucovance ; certain medications for irregular heartbeat such as amiodarone cordarone, nexterone, pacerone , quinidine, procainamide , and sotalol betapace, betapace af, sorine, sotylize ; nonsteroidal anti-inflammatory drugs nsaids such as ibuprofen advil, motrin, others and naproxen aleve, naprosyn, others ; probenecid probalan in col-probenecid, ; and theophylline elixophyllin, theo-24, uniphyl, others .
A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reportedWhether this interaction also occurs with the intravenoustopicalor vaginal preparations of miconazole is not known.
There are no adequate and well-controlled studies in pregnant women with Glucovance or its individual componentsNo animal studies have been conducted with the combined products in GlucovanceThe following data are based on findings in studies performed with the individual products.
Older adults may be more sensitive to the side effects of this drugespecially lactic acidosis or low blood sugar.
Glucovance is capable of producing hypoglycemia or hypoglycemic symptomsthereforeproper patient selectiondosingand instructions are important to avoid potential hypoglycemic episodesThe risk of hypoglycemia is increased when caloric intake is deficientwhen strenuous exercise is not compensated by caloric supplementationor during concomitant use with universal pharmacy online. other glucose-lowering agents or ethanolRenal or hepatic insufficiency may cause elevated drug levels of both glyburide and metformin hydrochlorideand the hepatic insufficiency may also diminish gluconeogenic capacityboth of which increase the risk of hypoglycemic reactionsElderlydebilitatedor malnourished patients and those with adrenal or pituitary insufficiency or alcohol intoxication are particularly susceptible to hypoglycemic effectsHypoglycemia may be difficult to recognize in the elderly and people who are taking beta-adrenergic blocking drugs.
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