But for this benefit there is a substantial cost that must be considered when choosing an anti-emetic these drugs are around 20 times more expensive than metoclopramide in most markets.
Risk of developing tardive dyskinesia increases with treatment duration and total cumulative dose.
If you’ve ever had muscle movement problems after using metoclopramide or similar medicines.
Stop taking metoclopramide and call your doctor at once if you have any of these SIGNS OF A SERIOUS MOVEMENT DISORDERwhich may occur within the first 2 days of treatment:
NEVER USE METOCLOPRAMIDE IN LARGER AMOUNTS THAN RECOMMENDEDOR FOR LONGER THAN 12 WEEKSHigh doses or long-term use of metoclopramide can cause a serious movement disorder that may not be reversibleThe longer you use metoclopramidethe more likely you are to develop this movement disorderThe risk of this side effect is higher in diabetics and older adultsespecially women
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methemoglobinemia has occurred in premature and full-term neonates who were given overdoses of metoclopramide 1 to 4 mg kg day orally, intramuscularly or intravenously for 1 to 3 or more days .