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Selective Serotonin Reuptake Inhibitors/Serotonin Norepinephrine Reuptake Inhibitors and Serotonin Syndrome.
Following oral administration of 14 C-labelled rizatriptanrizatriptan accounts for about 17of circulating plasma radioactivity.
Hormonal imbalances in womenfluctuations in oestrogenespecially during menopause or pregnancy seem to trigger a migraine.
Cases of life-threatening serotonin syndrome have been reported during combined use of selective serotonin reuptake inhibitorsSSRIsor serotonin norepinephrine reuptake inhibitorsSNRIsand triptansThere have been reports describing patients with symptoms compatible with serotonin syndromeincluding altered mental statusautonomic instability and neuromuscular abnormalitiesfollowing the use of SSRIs or serotonin norepinephrine reuptake inhibitorsSNRIsand triptans.
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