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Controlled clinical studies of bupropionimmediate-release formulationconducted in normal volunteersin subjects with a history of multiple drug abuseand in depressed patients showed some increase in motor activity and agitation/excitement.
ConclusionBupropion has played and will continue to play an important role as a treatment for major depressive disorder in adultsas well as for other related disorders.
Lightheadednessdizzinessor fainting loss of consciousness slow or irregular heartbeat unusual tiredness.
The therapeutic effect of bupropion is presumed to bein partdue to the antidepressant activity of 3 metaboliteshydroxybupropionthreohydrobupropionand erythrohydrobupropion3 Using cells expressing human transporters for DANEand serotoninit has been shown in vitro that bupropiontogether with the active metabolitesinhibits both the NE and DA human transportersdata on fileGlaxoSmithKlineResearch Triangle ParkN.CInhibition of serotonin reuptake was negligible even at the highest concentrations tested.
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