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In patients with pre-existing hypertriglyceridemiaestrogen therapy may be associated with elevations of plasma triglycerides leading to pancreatitis and other complications.

ESTRACE should not be used inwomen with undiagnosed abnormal genital bleedingknownsuspected or history of breast cancerknown or suspected estrogen-dependent neoplasiaactive deep vein thrombosispulmonary embolism or a history of these conditionsactive arterial thromboembolic diseasefor examplestrokemyocardial infarctionor a history of these conditionsknown anaphylactic reaction or angioedema to ESTRACEliver dysfunction or diseasethrombophilic disordersknown or suspected pregnancy.

Changes in vaginal bleeding pattern and abnormal withdrawal bleeding or flowbreakthrough bleedingspottingdysmenorrhea.

The distribution of exogenous estrogens is similar to that of endogenous estrogensEstrogens are widely distributed in the body and are generally found in higher concentrations in the sex hormone target organsEstrogens circulate in the blood largely bound to sex hormone binding globulinSHBGand albumin.

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