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Drugs whose efficacy is impaired by phenytoin include azoles fluconazole, ketoconazole, itraconazole, voriconazole, posaconazole , corticosteroids, doxycycline, estrogens, furosemide, irinotecan, oral contraceptives, paclitaxel, paroxetine, quinidine, rifampin, sertraline, teniposide, theophylline, and vitamin d.

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With acid secretion broken by protonix pantoprazole unlikely zantac could do anything.

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