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Cytoxan and its metabolites are dialyzable although there are probably quantitative differences depending upon the dialysis system being usedPatients with compromised renal function may show some measurable changes in pharmacokinetic parameters of Cytoxan metabolismbut there is no consistent evidence indicating a need for Cytoxan dosage modification in patients with renal function impairment.
Nervous Systemencephalopathyconvulsiondizzinessneurotoxicity has been reported and manifested as reversible posterior leukoencephalopathy syndromemyelopathyperipheral neuropathypolyneuropathyneuralgiadysesthesiahypoesthesiaparesthesiatremordysgeusiahypogeusiaparosmia.
Hepatic imparimentGive 75of normal dose if transaminase levels are3 times upper limit of normal or bilirubin is 3.1-5 mg/dL.
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