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Zyloprim and its primary active metaboliteoxipurinolare eliminated by the kidneysthereforechanges in renal function have a profound effect on dosageIn patients with decreased renal function or who have concurrent illnesses which can affect renal function such as hypertension and diabetes mellitusperiodic laboratory parameters of renal functionparticularly BUN and serum creatinine or creatinine clearanceshould be performed and the patient’s dosage of Zyloprim reassessed.

Enhanced bone marrow suppression by cyclophosphamide and other cytotoxic agents has been reported among patients with neoplastic diseaseexcept leukemiain the presence of ZyloprimHoweverin a well-controlled study of patients with lymphoma on combination therapyZyloprim did not increase the marrow toxicity of patients treated with cyclophosphamidedoxorubicinbleomycinprocarbazineand/or mechlorethamine.

Contact your doctor if you experience these side effects and they are severe or bothersomeYour pharmacist may be able to advise you on managing side effects.

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allopurinol a drug trade name zyloprim used to treat gout and other conditions in which there is an excessive buildup of uric acid.

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