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Encephalopathy has been reported in association with cerebellar toxicity characterized by ataxiadizzinessand dysarthriaCNS lesions seen on MRI have been described in reports of encephalopathyCNS symptoms are generally reversible within days to weeks upon discontinuation of metronidazoleCNS lesions seen on MRI have also been described as reversible.
Hemodialysis removes significant amounts of metronidazole and its metabolites from systemic circulationThe clearance of metronidazole will depend on the type of dialysis membrane usedthe duration of the dialysis sessionand other factorsIf the administration of metronidazole cannot be separated from the hemodialysis sessionsupplementation of metronidazole dosage following the hemodialysis session should be considereddepending on the patient’s clinical situationsee CLINICAL PHARMACOLOGY
GYNECOLOGIC INFECTIONSincluding endometritisendomyometritistuboovarian abscessand postsurgical vaginal cuff infectioncaused by Bacteroides species including the Bfragilis groupClostridium speciesPeptococcus speciesPeptostreptococcus speciesand Fusobacterium species.
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LOWER RESPIRATORY TRACT INFECTIONSincluding pneumoniaempyemaand lung abscesscaused by Bacteroides species including the Bfragilis group.
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