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Take this medication by canadieean pharmacy support group. mouth as directed by your doctorusually once dailySome brands of this medicationthose containing metoprolol tartratemay be better absorbed when you take them with or right after a mealOther brandsthose containing metoprolol succinatemay be taken with or without foodFollow your doctor’s directions for your brandand take it the same way at the same time each day.

Tell your doctor if you haveor have hadany medical conditionsespecially the following:

Although beta-adrenergic receptor blockade is useful in the treatment of anginahypertensionand heart failure there are situations in which sympathetic stimulation is vitalIn patients with severely damaged heartsadequate ventricular function may depend on sympathetic driveIn the presence of AV blockbeta-blockade may prevent the necessary facilitating effect of sympathetic activity on conductionBeta 2adrenergic blockade results in passive bronchial constriction by interfering with endogenous adrenergic bronchodilator activity in patients subject to bronchospasm and may also interfere with exogenous bronchodilators in such patients.

The precise mechanism for the beneficial effects of beta-blockers in heart failure has not been elucidated.

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