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Th inhibitoy activity aciclovi is highly slctiv du tits ainity th nzym thymidin kinas (TK) ncodd by HSV and VZV. This vial nzym convts aciclovi intaciclovi monophosphat, a nuclotid analogu. Th monophosphat is uth convtd intdiphosphat by cllula guanylat kinas and inttiphosphat by a numb cllula nzyms. In vit, aciclovi tiphosphat stops plication th hps vial DNA. This is accomplishd in th ways: 1) comptitiv inhibition vial DNA polymas; 2) incopoation intand tmination th gowing vial DNA chain; and 3) inactivation th vial DNA polymas. Th gat antivial activity aciclovi against HSV compad with VZV is du tits micint phosphoylation by th vial TK.
Aciclovi is a synthtic puin nuclosid analogu with in vitand in vivinhibitoy activity against hps simplx vius typ 1 (HSV-1) and typ 2 (HSV-2), and vaiclla-zost vius (VZV).
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