Colchicine may rarely cause a certain serious even fatal muscle damage rhabdomyolysis .
Colchicine is used to prevent gout attackssuddensevere pain in one or more joints caused by abnormally high levels of a substance called uric acid in the bloodin adultsand to relieve the pain of gout attacks when they occurColchicine is also used to treat familial Mediterranean feverFMFan inborn condition that causes episodes of feverpainand swelling of the stomach arealungsand jointsin adults and children 4 years of age and olderColchicine is not a pain reliever and cannot be used to treat pain that is not caused by gout or FMFColchicine is in a class of medications called anti-gout agentsIt phizer viagra for sale . works by stopping the natural processes that cause swelling and other symptoms of gout and FMF.
No dedicated pharmacokinetic study has been conducted using colchicine capsules in patients with varying degrees of renal impairmentColchicine is known to be excreted in urine in humans and the presence of severe renal impairment has been associated with colchicine toxicityUrinary clearance of colchicine and its metabolites may be decreased in patients with impaired renal functionDose reduction or alternatives should be considered for the prophylaxis of gout flares in patients with severe renal impairmentColchicine is not effectively removed by hemodialysisPatients who are undergoing hemodialysis should be monitored carefully for colchicine toxicity.
Taking certain medicines with colchicine capsules can cause your level of colchicine to be too highespecially if you have kidney or liver problemsTell your healthcare provider about all your medical conditionsincluding if you have kidney or liver problemsYour dose of colchicine capsules may need to be changedEven medicines that you take for a short period of timesuch as antibioticscan interact with colchicine capsules and cause serious side effects or death.
Published reports on the pharmacokinetics of intravenous colchicine in patients with severe chronic liver diseaseas well as those with alcoholic or primary biliary cirrhosisand normal renal function suggest wide inter-patient variabilityIn some subjects with mild to moderate cirrhosisthe clearance of colchicine is significantly reduced and plasma half-life prolonged compared to healthy subjectsIn subjects with primary biliary cirrhosisno consistent trends were notedSee Hepatic ImpairmentNo pharmacokinetic data are available for patients with severe hepatic impairmentChild-Pugh C
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